Upregulation of Parkin in Endophilin Mutant Mice
نویسندگان
چکیده
منابع مشابه
Upregulation of Parkin in endophilin mutant mice.
Several proteins encoded by PD genes are implicated in synaptic vesicle traffic. Endophilin, a key factor in the endocytosis of synaptic vesicles, was shown to bind to, and be ubiquitinated by, the PD-linked E3 ubiquitin ligase Parkin. Here we report that Parkin's level is specifically upregulated in brain and fibroblasts of endophilin mutant mice due to increased transcriptional regulation. St...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1710-14.2014